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Unlike TMZ, the alkylating agent lomustine generates O6-chloroethylguanine (O6-ChlEtG) adducts

Sindrup SH, Graf A, Sfikas N

For example, hepatic CDO activity is very low in animals fed a low-protein diet (e.g., 100 g casein per kg diet) but increases dramatically when the protein level in the diet is increased to 200 g/kg (near the requirement) and even more when it is increased to 400 g/kg (excess of the requirement), with the new steady-state levels of CDO activity being reached within hours of the diet change (Bella et al

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