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These effects are usually short-lived and go away on their own

Richard Horowitz describes the Jarisch-Herxheimer (JH) flare as a temporary worsening of the symptoms of Lyme disease that occurs when the Lyme spirochete is being killed off by antibiotics, creating inflammationThese JH reactions produce cytokines (TNF-alpha, IL-6, and IL-8), which then create inflammatory symptoms, including increased fever, muscle and joint pain, headaches, cognitive impairment, and a general worsening of the underlying symptomology

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ROS can also cause an imbalance in mitochondrial metabolism, causing change in membrane permeability and halting the ATP production, which in turn cause cell cycle alterations, ultimately leading to the cancer appearance (Figure 2) [21]