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Bifunctional PEGylated exenatide-amylinomimetic hybrids to treat metabolic disorders: an example of long-acting dual hormonal therapeutics

In preclinical studies, researchers constructed Arginine-Glycine-Aspartic acid-Human Serum Albumin-Tacrolimus (RGD-HSA-TAC) nanoparticles to target the delivery of tacrolimus to podocytes, which resulted in a reduction of podocyte injury and albuminuria in mice with diabetic kidney disease (148)