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This neuroprotective effect may be mediated by the upregulation of monocyte chemoattractant protein-induced protein 1 (MCPIP1), as the neuroprotection and anti-inflammatory effect were inhibited upon knockdown of MCPIP1 using specific small interfering RNA (siRNA) (Wang M

MTP Press, Boston, 1985). Conjugated metabolites that are pharmacologically active are not often successfully developed into drugs, whereas there are many examples of active Phase I metabolites that become drugs