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& Portinaro, N

Conversely, the SSG of transglutaminase 2 at Cys193 promotes its degradation, sensitizing colon cancer cells to 5-fluorouracil by restoring apoptosis (95)

Cartilage and osteoarthritis models: Studies in rats with induced osteoarthritis show BPC-157 reducing cartilage degradation and protecting against disease progression

Specifically, lactate triggers mitochondrial fission 1 (Fis1) lactylation at lysine 20, which promotes excessive mitochondrial fission, leading to ATP depletion, mtROS overproduction, and mitochondrial apoptosis, exacerbating S-AKI