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10.3389/fphar.2021.628988 Front Pharmacol

In addition, tryptophan 104 plays a key role in the weaker site 2 interaction ( Crystallographic studies comparing the unliganded ECD of GHR to the ligand-bound form showed no major change in overall structure

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In line with this notion, our laboratory is currently exploring whether the M105I mutation alters SNARE-independent proteinprotein interactions of -SNAP