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A single vial containing all three compounds in a fixed ratio eliminates that friction

The 25-mg twice-weekly dose has been largely replaced by the 50-mg prefilled syringe and auto-injectors, which are equally effective

While such a blood type mismatch is not uncommon, it can result in alloimmunization when combined with fetal-maternal bleeding, which occurs in around 5% of pregnancies and increases throughout the gestation period [172]