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A condition in which serum vitamin B12 is normal of elevated, yet and at the same time metabolic markers pr symptoms suggest that the subject is vitamin B12 deficient Such conditions represent "Paradoxical B12 deficiency" Metabolic analysis suggests that functional deficiency in either folate or vitamin B2 is the cause of paradoxical B12 deficiency Resolution of Paradoxical deficiency requires complete resolution of functional B2 or folate deficiency Paradoxical B12 deficiency is commonly seen in conditions such as Autism Chronic Fatigue Syndrome Hypothyroidism Various malignancies Long COVID All cause mortality Persons with Paradoxical B12 deficiency are more likely to die from COVID-19 The current dogma on vitamin B12 deficiency implies a direct link between levels of serum vitamin B12, and sufficiency

Research indicates that IL-22 can mitigate autophagosome formation via the Beclin1 pathway, thus alleviating the severity of AP (124)

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Within four to six weeks, the RBC count usually returns to normal levels