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Di-PKM2 interacts with STAT3 and -catenin, regulates the transcription of MEK5, Cyclin D1, GLUT1, and LDHA, induces aerobic glycolysis, and promotes the proliferation, migration, and osteogenesis of VSMCs [98]

This observation further supports the pivotal role of the CINC-3/CXCR2 signaling axis in sustaining persistent neuroinflammation following traumatic peripheral neuropathy