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The mechanism involves cellular reactive oxidative stress, cell proliferation inhibition, senescence, apoptosis, and regulation of MAPK-ERK1/2 signaling, leading to a reduced number of mature oocytes (111)

[2] Cell Line:GH3/B6 cells Concentration:1 mg/mL Incubation Time:24 h Result:Induced sub G1 events, and DNA fragmentation, which was correlated with the number of the apoptotic cells