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Conversely, sleep deprivation and circadian disruption increase mast cell activation

In some cases, more aggressive treatment protocols are recommended

Marine Mammal Ecotoxicology: Academic Press

Importantly, BPC 157, but not PDGF-BB, stimulated earlier maturation of granulation tissue, soluble collagen concentration in the exudates (using sponge implantation), and organized collagen significantly more in wounds (i.e., on day 12 after daily treatment) (Tkalcevic et al., 2007)