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The presence of heparanase on the cell surface and in membrane extensions is involved in the migratory activity of mature DCs

10.2147/ott.s259114 OncoTargets Ther

Its natural role, as found in the human body, includes the activation of a wide range of skin health functions, including healing, immune function, collagen synthesis, production of fibroblasts (cells that work as collagen/elastin factories) and anti-inflammatory responses

Chronic UV exposure degrades both collagen fibers and the proteoglycan ground substance of the dermis, producing the leathery texture and deep wrinkles characteristic of photodamaged skin