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Description

The system consists of a heterodimer composed of the light chain xCT (SLC7A11) and the heavy chain 4F2 (SLC3A2), which mediates a 1:1 exchange between intracellular glutamate and extracellular cystine

Fries GR, Walss-Bass C, Bauer ME, Teixeira AL

(2006) Acta Crystallogr D Biol Crystallogr 62 : 197-207 PubMed: 16421451 Search on PubMed DOI: Primary Citation Related Structures: 1PKW, 1PKZ, 1PL1, 1PL2, 1XWG PubMed Abstract: Human glutathione transferase A1-1 is a well studied enzyme, but despite a wealth of structural and biochemical data a number of aspects of its catalytic function are still poorly understood