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Sglt-2 inhibitors in diabetes: A focus on renoprotection

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Also, the cumulative need for colectomy after 10 years was 9.8%, nearly 50% of the patients were relapse-free in the last five years of the study, and only 20% of the patients with proctitis or left-sided disease progressed to pancolitis

122,123,124 Mammalian CYPs are a family of heme-containing NAD(P)H-dependent monooxygenases that metabolize numerous endogenous metabolites, including fatty acids and steroids, and exogenous substrates, including carcinogens, pesticides and drugs, resulting in continuous production of ROS