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Several investigations have found evidence of abnormal oxidative stress in children with autism, including laboratory biomarkers of decreased antioxidant enzymes (e.g., superoxide dismutase, transferrin, and ceruloplasmin) and elevations in biologic measures of oxidative stress (including increased lipid peroxidation and impaired plasma methionine methylation capacity) [14, 15]

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NAD + is reduced by 70% within 3 to 24 months, and as a compensation, the concentration of NADH has increased by 50%

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