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For optimal effectiveness, healthspan-extending interventions might need to start earlier, which means that pharmaceutical treatments would be delayed until individuals are already experiencing a decline, potentially reducing their efficacy and benefits

These changes in fatty acids are indicative of a reduction in the production of inflammatory eicosanoids from AA and an increase in antiinflammatory mediators such as resolvins and protectins

In some cases, they can mask symptoms of more serious conditions, delaying necessary medical treatment

(d) Simultaneously, the drug has to be rapidly cleared from the blood and healthy tissue