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Oxidative stress in sepsis: a redox redux

The enrichment of differentially expressed genes in the mTOR pathway in connection with sterol regulatory elements binding proteins ( Figures 3A, C ) is also interesting and in line with recent reports showing that the mTOR-driven metabolic reprogramming of macrophages increased flux through the mevalonate pathway and this process is involved in trained immunity (57)

FGF21 is known for its effects on regulating glucose and lipid metabolism, increasing insulin sensitivity, and promoting energy expenditure