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Description

Fumarase deficiency halts the TCA cycle, leading to fumarate accumulation, which in turn contributes to the upregulation of hypoxia-inducible factor-1 (HIF-1), a transcription factor that facilitates cellular adaptation to hypoxia by promoting aerobic glycolysis

At lower temperatures, the level of MDA increased, which is indirect evidence of lipid peroxidation

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Our skin wrinkles, our joints creak, and decreased energy levels start to slow us down But for many adults, the most jarring aspect of aging is the gradual decline of cognitive function