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Altogether, ALS exemplifies the profound complexity of neurodegenerative diseases characterized by neuronal loss

G6PD catalyzes the first step in the pentose phosphate pathway (equivalently, the hexose monophosphate shunt) to generate NADPH which is subsequently utilized in processes that reduce hydrogen peroxide (H 2 0 2 ) to water, ameliorating oxidative stress in red blood cells (RBCs)

Biophysics 639, 1625

475 Deletion of the ZIP2 gene notably intensified myocardial I/R injury, whereas upregulation of ZIP2 demonstrated the potential to mitigate I/R injury