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Conclusions In summary, we demonstrated that PPAR activation inhibits chondrocyte ferroptosis in osteoarthritis and that this chondroprotective effect is associated with the activation of Pink1/Parkin-dependent mitophagy

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Clarke CN, Lee MS, Wei W, Manyam G, Jiang ZQ, Lu Y, Morris J, Broom B, Menter D, Vilar-Sanchez E, Raghav K, Eng C, Chang GJ, Simon I, Bernards R, Overman M, Mills GB, Maru D, Kopetz S