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Patients were randomized into three different treatment arms for 48 hours: Bolus group (bl) = furosemide 80 mg IV boluses, twice daily Continuous group (cIv) = IV furosemide 160 mg/day, given as a continuous infusion over 16 hours Hyperdiuresis group (HSS) = 160 mg IV furosemide plus 150 ml of 2% NaCl, twice daily infused over 30 minutes Patients in the hyperdiuresis group had shorter hospital length of stay (table below)

The tyrosine addition to AOD-9604 does a few things: Better stability The tyrosine at the N-terminus makes the molecule more resistant to enzymatic degradation, extending its functional half-life

It builds on the progress of earlier compounds like Semaglutide and Tirzepatide by activating three key hormonal pathways involved in appetite

There could be a variety of reasons