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All chronic diseases, including COVID-19 with the long-COVID-19-syndrome (271), are characterized by the presence of persistent chronic inflammation and sustained generation of reactive oxygen and nitrogen species that when confronted with inadequate antioxidant defenses (likely leading components of anti-inflammaging) precipitate excessive oxidative stress

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Onder natuurlijke omstandigheden wordt glutathion continu aangemaakt, maar de aanmaak kan afnemen bij bijvoorbeeld veroudering, stress of blootstelling aan toxines