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Conversely, the rise in cholesterol esters may reflect an adaptive response, wherein astrocytes store lipids in LDs to shield them from peroxidation

Conclusion The four commonly used IC/BPS rat models (HCL, AA, PS + LPS, and CYP) differed significantly in their histopathological patterns and GO and KEGG pathways, which demonstrated that none of these rat models could fully reflect the complexity of IC/BPS

Based on these findings and clinical experience, the WMS 2024 guidelines recommend nifedipine (30 mg sustained release twice daily) only when descent is impossible/delayed and oxygen is unavailable

The mixing parameter controls the balance between the L1 and L2 penalties