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Results Tumor cells outcompete T cells for cystine uptake, leading to T-cell exhaustion and death Firstly, we compared the capability of cystine uptake between T cells and tumor cells, confirming that SLC7A11 , the functional subunit of system Xc-, was upregulated in various human tumors (Supplementary Fig

Hyperglycemia-induced epigenetic reprogramming in pulmonary DCs suppresses MHC-II and costimulatory molecule expression via histone hyperacetylation, blunting antigen presentation and CD8 + T-cell priming (Figure 5)

Evaluation on infectivity of babesia microti to domestic animals and ticks outside the ixodes genus

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