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The results of another randomized, double-blinded, placebo-controlled trial suggest that oral melatonin, combined with the first adjuvant chemotherapy for breast cancer (ACBC), can counteract dysfunction of the inhibitory descending pain regulatory system (DPMS) and reduce serum levels of neuronal and astrocyte neuroplasticity markers (i.e., BDNF, S100B proteins, and TrkB), thus improving pain perception indicators [58]

Children: 1/4 teaspoon for every 30 lb of weight daily Best to take serving in the morning on an empty stomach

This results in the activation of microglia (resident immune cells in the brain) and the subsequent neuroinflammatory cascade in the CNS, which has been shown to contribute to cognitive deficits (Nuszkiewicz et al., 2024)

MDA is an end product of a lipid peroxidation reaction and an indicator of oxidative stress