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The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial

The duration of postoperative hospitalization was shorter in the CT group than in the SS group ( t = 2.258, P = 0.028)

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However, the exact mechanisms underlying these phenomena are not yet fully understood and clinical trials targeting NNMT have not been reported until now