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Figure 11 Figure 12 The BNST, which is also referred to as the extended amygdala, receives input from the hippocampus and shares reciprocal projections with the paraventricular nucleus of the thalamus (246, 293296)

This mechanism prevents the metabolic slowdown that typically accompanies significant weight loss

Acknowledgements We acknowledge co-funding from the Fondazione per la Ricerca Biomedica Saverio e Isabella Cianciola and from Next Generation EU, in the context of the National Recovery and Resilience Plan, Investment PE8 Project Age-It: Ageing Well in an Ageing Society

Experience of sapropterin dihydrochloride monotherapy is mainly limited to mild forms of PTPSD with minimal or even absent clinical symptoms, and normal levels of dopamine and serotonin metabolites in CSF [44]