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Specifically, sulfasalazine, an XCT inhibitor, appears useful in the treatment of pancreatic and small-cell lung cancer cells 69,70 , while NOV-002, a glutathione disulfide mimetic that alters the GSSG/GSH ratio and induces oxidative stress, has been favorably used in patients with HER2-negative breast cancer 71

These changes correlate with the weakened circadian signals (for instance, a dampened melatonin rhythm and blunted nighttime drop in body temperature) that normally consolidate sleep at night

Front Endocrinol 4:138

In another study, genotyping by multiplex PCR of GST-M1 and GST-T1 in 101 Egyptian women with nonsegmental vitiligo vulgaris and 101 age female healthy matched controls show that the absence of GST-M1 gene and the presence of the GST-M1/GST-T1 double-null genotype represent a risk factor for vitiligo in these women ( p = 0.01