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HMGB1 secretion, in particular, plays a pivotal role in promoting bone marrow-derived DC recruitment and activation, enhancing antigen presentation and T cellmediated anti-leukemia responses ( in vitro , highlighting the therapeutic potential of reactivating the ferroptosisHMGB1 axis in resistant CML (Sun et al., 2023)

This research was supported by the following grants to KM: American Diabetes Association, American Heart Association, NIH NIEHS, NIH NIA, NIH NINDS, NS053956, and NIH ARRA

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The solution remains stable for approximately six weeks under these conditions, though many researchers prefer to use it within four weeks for maximum potency