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Additionally, impaired erythropoietin (EPO) synthesis and vitamin D deficiency can cause renal anemia and renal osteodystrophy (13, 1820)

See also this post on how CR appears to protect bone against age-related decline in bone quality /microarchitecture, for which the available human evidence is now in support, or at least to which it offers no contradiction.(35) Menatetrenone seems promising for CR-related low bone mass, as the actual MASS of bone is constrained by low energy intake, whereas menatetrenone primarily appears to reduce risk by preseving QUALITY -- a more likely viable strategy.Arginine and lysine: these have been found to be surprisingly effective in reducing AGE and AGE-induced complications of diabetes, especially in the kidneys but also apparently in the heart (6-12a)

Elderly dogs will suffer from various diseases due to decreased immune function