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With respiratory depression or obstructive airway diseases (i.e., asthma, COPD, obstructive sleep apnea, obesity hyperventilation, also known as Pickwickian syndrome) With liver failure With known intolerance to fentanyl or other morphine-like drugs, including codeine or any components in the formulation

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Pathophysiological Implications of Hypoxia in Human Diseases

Interestingly, among the ongoing clinical trails, lowering the IOP remains the primary focus