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doi: 10.1111/j.1572-0241.2003.07238.x

World J Clin Cases 10:3662

Future studies should prioritize validation in human-relevant models (e.g., induced pluripotent stem cell-derived dopaminergic neurons, brain organoids, humanized animal models) to better recapitulate the chronic, progressive nature of human PDan area where current acute toxin-induced rodent models are insufficient

Equally important is the evaluation of non-pharmacologic interventions, which have demonstrated benefit in other chronic pain populations but remain largely untested in patients with liver disease