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The findings were attributed to the patients status of extensive or ultrarapid metaboliser of CYP2D6 that was able to overcome the inhibition of CY2D6 and 3A4 activity promoted by ritonavir

The mononuclear phagocyte system, consisting of a number of cell types including monocytes and macrophages, is part of both humoral and cell-mediated immunity and has an important role in defence against microorganisms, including mycobacteria, fungi, bacteria, protozoa and viruses

Thiffault et al., 2000) and cells (Hartley et al., 1994

Associations of mthfr gene polymorphisms with hypertension and hypertension in pregnancy: A meta-analysis from 114 studies with 15411 cases and 21970 controls