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Thymosin Beta-4 has been studied in Phase II clinical trials for corneal wound healing, where it showed significant improvement compared to placebo

This action, in turn, increases LDL receptor expression 25,26,27

Another metabolic pathway altered by fumarate accumulation is the PNC, where the increase of fumarate causes the reversal of adenylosuccinate lyase to form adenylosuccinate, altering de novo purine biosynthesis [19] and making cells reliant on the salvage pathway to support purine synthesis