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While low to moderate levels of ROS are essential in various physiological processes, their excessive and uncontrolled production causes failure of endogenous defences, leading to oxidative stress (OS) and possibly causing damage to the proteins, lipids, and DNA

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What You Should Know NAD+ functions as a coenzyme for energy metabolism and activates repair proteins called sirtuins Glutathione neutralizes free radicals and supports detoxification as your primary antioxidant defense From ages 20 to 60, NAD+ drops by 50%, while glutathione synthesis decreases by 45% The molecules support one another through NADPH production pathways that regenerate active glutathione

Consequently, the inhibitory ability of the modified peptide was enhanced by approximately three-fold compared to that of p53 TAD PEP (Figure