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17 Danforth E Jr, Burger A

2018, Aug

Abstract Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes

Additionally, it was demonstrated, that failure PINK/PARKIN axis expression favors the accumulation of defective mitochondria that are not removed from the cells due to the impaired lysosomal system which in consequence promotes cellular damage, generates oxidative stress, and impairs sensitivity for insulin [60]