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Itaconate, derived from citrate produced in the TCA cycle, contains ,-unsaturated carboxylic acid, and covalently modifies at the Cys151 residue of Keap1 (78)

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1 Introduction Air pollution has become a global disease burden, contributing to 7.6% of the total annual mortality rate and 103.1 million deaths annually ( Overweight and obesity are characterized by the expansion of white adipose tissues (WATs), which occurs due to the storage of excessive lipid droplets, particularly in gonadal WAT (gWAT) and subcutaneous WAT (sWAT) ( As the main site for the oxidation of fatty acids, mitochondria are crucial for maintaining the balance of lipid metabolism ( The real-ambient exposure system that was previously established in Shijiazhuang city was applied in this study ( In our study, we examined the hypertrophy of adipose tissue in young mice, identified the disorder of lipid metabolism with multi-omics analysis and illustrated the increased mitochondrial activity in the real-ambient exposure system