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We noted that under the methodology proposed in section III.A.2.c of this rule, in circumstances in which some, but not all NDCs of a single or multiple source drug are negative or zero, we would similarly calculate the payment limit using only NDCs with positive manufacturer's ASP data from the given quarter and omitting those that had declined to zero or a negative value in ASP or sales

Device preparation The fluidic channels were fabricated using a CO 2 laser cutter machine (100 W, CMA-1390 Yueming laser, Dongguan, China) on transparent sheets of polymethyl methacrylate (PMMA) and polyvinyl chloride (PVC, thickness = 100 m, GBC) and double-sided pressure sensitive adhesive (PSA, thickness, =80 m, Flexcon, Massachusetts, USA)