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These authors found that toxic IAPP oligomers initially appear within the granules in the secretory pathway, where they disrupt the membranes of the granules, leading to their release into the cytoplasm

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Pharmacol Res 97:16 Cardinali A, Linsalata V, Lattanzio V, Ferruzzi MG (2011) Verbascosides from olive mill waste water: assessment of their bioaccessibility and intestinal uptake using an in vitro digestion/Caco-2 model system

Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles