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Under oxidative stress, NRF2 translocates into the nucleus and forms a heterodimer with small musculoaponeurotic fibrosarcoma proteins and binds to the antioxidant response element consensus sequence for transcriptional regulation (196) ( Figure 3 )

The reasons for liver failure during machine perfusion has yet been unexplored and multifactorial with methaemoglobinaemia and poor oxygen delivery playing a role

Injection of PPI (3 mg/kg, dissolved in 1% DMSO +5% PEG300 + 5% Tween 80 + 89% deionized water), as described previously [26], or the control solution with the same solvent

[20] Despite initially being back-up to Gustavo Muna, [21] Navas was the first-choice goalkeeper for Levante in the 201314 season, and was nominated as the league's best goalkeeper alongside Thibaut Courtois of Atltico Madrid and Willy Caballero of Mlaga CF, [22] going on to win the prize