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By modifying the surface of nanoparticles, researchers can enable them to respond to specific physiological features of the GC microenvironment, such as acidic pH, elevated ROS levels, and high esterase activity, thereby achieving an activation-and-release profile in tumor tissues while remaining dormant in normal tissues

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The authors proposed that 17-estradiol may act via an antioxidant mechanism, thus reducing the propagation of reactive oxygen species

Bray-Curtis dissimilarity analysis indicated substantial compositional divergence between groups (Figure S4A-B)