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Common side effects tend to be mild and go away the longer you are on the medication

Subcutaneous administration achieves brain concentrations twice plasma levels (t 1/2 ~10.5 hr) with no toxicity observed at 15 the therapeutic dose in rats

doi: 10.5114/ceji.2020.103422 66 PrakashAGoaKL

Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use were it to become clinically available patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation