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For instance, -hydroxybutyrate (OHB) inhibits histone deacetylases, thereby engaging epigenetic mechanisms and anti-inflammatory pathways, and has been implicated in initiating anti-inflammatory cascades that counteract the pathology of neurological disease

When co-cultured with DCs treated similarly, MSU crystals induce the latter to release IL-1/, prompting the activation of the NF-B signaling pathway within CD4+ T cells

Since riboflavin deficiency results in low FMN and FAD contents in the cells, it is plausible that the activities of the flavin-containing enzymes are decreased simultaneously 20

Another study showed that radiotherapy in combination with IKE or sorafenib in both CDX and PDX is effective for tumor suppression [12]