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This integration can be achieved through various deployment strategies and within relatively brief release periods, with an average duration of 11 weeks and a range spanning from 2 to 22 weeks [293]

In addition, ADCs can also exert an extracellular action on neighbouring cells via the release of the payload after intracellular cleavage of the linker (bystander effect), which is mediated by the proteases localised in lysosomes

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