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Apoptosis plays a key role in CNS diseases, which not only regulates the life and death of neural precursor cells, differentiated neurons and glial cells through the balance of Bcl-2 family proteins during neural development, but also shapes the neural structure

Journal of Biological Chemistry, 293 (20), 75227530

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Total protein levels of Bcl-2 were significantly decreased (77.6 6.1%) but the total protein levels of Bax and cleaved caspase-3 were significantly increased (598.2 69% and 291.4 23.5%, respectively) in the livers of APAP-treated rats as compared to control rats ( Fig