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in Brain Peptides: A New Endocrinology, 7188 (Elsevier/North-Holland Biomedical Press, 1979)

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among those, stronger evidence exists for metabolic disorders, allergies, autoimmune diseases, disturbances of the central nervous system, and some forms of cancer (Fitzgibbon and Mills 2020)

Their major limitations include: (1) Their immunogenicity which can create an inflammatory response in the donor which can lead to degeneration of the transducted tissue, (2) they can produce non-specific toxins, (3) due to the semi-random integration to the genome, there is a theoretical risk of insertional mutagenesis, (4) they have limitations of transgenic capacity size