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TB-500 has been examined in brain injury and neurodegeneration models with research documenting neuronal cell survival promotion through PI3K/Akt anti-apoptotic signalling, promotion of neurogenesis and oligodendrocyte progenitor migration following white matter injury, and anti-inflammatory effects in the injured CNS

[Abstract]2023 May 2;119(4):1030-1045

Conclusion This study indicates the presence of GST alpha and pi especially in the epithelium and sputum supernatants in mild/moderate COPD and low expression of GST alpha in the epithelium in cases of very severe COPD

Several in vitro studies also demonstrated that TrxR1 and selenoprotein P could directly reduce the lipid hydroperoxide, 15-hydroperoxyeicosatetraenoic acid (15-HPETE), to its corresponding hydroxyl (15(S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid