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1 Introduction The tumor microenvironment (TME) is a complex and evolving entity The composition of TME varies depending on the type of tumor, but its hallmark features include immune cells, stromal cells, blood vessels, and extracellular matrix (ECM) ( + macrophages facilitate ECM accumulation through ligand-receptor interactions, thereby influencing the efficacy of immunotherapy for liver cancer ( In 2020, primary liver cancer emerged as the sixth most prevalent cancer globally and the third most fatal ( This review aims to investigate the metabolic interactions between cancerous and non-cancerous cells within the microenvironment of liver cancer

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