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1) The cut off value of Numerical Rating Scale (NRS) score 4 for the presence of substantial fatigue was determined by analysis of the receiver operating characteristic (ROC) curve, in which original fatigue scale Grade 3 or 4 on HD day was defined as presenting with fatigue accompanying decreased activities of daily life (ADL) in the study (NRS = 3.75: sensitivity 0.909, specificity 0.764