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57,58 Although further studies are needed to clarify the role of astrocytic Hb in the nucleolus, our findings reveal a novel antioxidative mechanism mediated by its therapeutic potential to contribute to nuclear homeostasis and genomic stability and potentially mitigate neurodegenerative damage

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Particularly, selenium compounds possess a high capacity of exerting oxidative stress by oxidizing thiols and generating ROS, thereby termed as redox-active selenium compounds, e.g., selenocysteine, selenite, methyl selenic acid, and MeSeCys [89]

Chromium picolinate is an essential trace element that plays a significant role in carbohydrate, fat, and protein metabolism